What is Pathology - How are cells classed based on their ability to replicate?
All organs are made up of dividing cells throughout embryonic development. Some cells in the adult organism retain their ability to divide, whereas others become dormant and quit the mitotic cell cycle. As a result, there are three sorts of cells: -Continuously dividing cells (mitotic): These cells, also known as labile cells, are stem cells found in tissues that are continually renewing, such as the epidermis, the mucosal layer of internal organs, bone marrow, and the testis' seminiferous tubules. Throughout an adult's life, tissues made up of mitotic cells contain more than 1.5 percent cells in mitosis at any given time. - Mitotic cells that are not facultative: These cells, also known as stable cells, are in the G0 phase. In certain situations, they can enter the mitotic cycle and divide into two daughter cells. Organs made up of stable cells have the ability to regenerate and replace lost parenchymal cells with new cells of equal size. Most parenchymal organs, such as the liver, kidneys, and endocrine organs, are made up of stable cells. Stable cells include endothelial cells, fibroblasts, and other connective tissue cells. - Nondividing, postmitotic cells: These cells, also known as permanent cells, are unable to enter the mitotic cycle again. These cells cannot be replenished, thus an injury is usually treated by replacing them with cells that are incapable of performing their specific role. The brain and heart are models for organs made up of permanent cells. Because the reserve cells inside the muscle cannot entirely compensate for the loss of mature striated muscle fibres, skeletal muscle is also classed under this heading for practical purposes.
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