​What is Pathology – How is histamine released from mast cell ?

​What is Pathology – How is histamine released from mast cell ? 
Mast cells release histamine in a variety of ways. Mast cells respond to a variety of stimuli, including mechanical stimulation, anaphylatoxins produced by complement, and some neuropeptides, by releasing histamine. Histamine is released as a result of the interaction between antigen with immunoglobulin E (IgE) attached to the plasma membrane of mast cells in type I hypersensitivity reactions (e.g., hay fever).