What is Pathology - What are the different types of granulomas?
Pathogenetically, granulomas can be split into three groups: -Infectious granulomas: This group includes caseating granulomas, which are found in tuberculosis and some deep fungal infections, such as histoplasmosis or blastomycosis; syphilis gummas, which also contain plasma cells; and suppurative granulomas, which are found in cat scratch disease or bartonellosis and contain central areas of liquefactive necrosis caused by neutrophils. -Noninfectious granulomas: These granulomas are found in delayed cell-mediated immune reactions (e.g., hypersensitivity pneumonitis) and unclear origin disorders (e.g., sarcoidosis). Granulomas can occasionally be found in lymph nodes draining a tumor-affected area. There is no core caseating necrosis in these granulomas, which are mostly epithelioid macrophages with a few dispersed lymphocytes. - Foreign body granulomas: These are granulomas that grow around indigestible exogenous materials such surgical sutures, wood splinters, parasite ova, and so on. They have a lot of big cells in them. It is frequently feasible to identify the causal material within these huge cells, which is why they are referred to as foreign body giant cells.
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