What is Pathology - What are the most crucial ECM components built down during the healing of inflammatory lesions?
Extracellular components deposited during repair can be classified into three categories: Collagens, sticky proteins, and proteoglycans are the three types of proteins. Collagens :This category comprises 19 proteins that have been identified as fibrillar or nonfibrillar. The following are the most important: Collagen type I is the most common structural protein in the body. It is found in most organs and is the major component of connective tissues, tendons, and bones. It has a triple helical shape that gives tissues strength and structure. Collagen type III: This protein is common in embryonic tissues and is abundant in malleable organs and blood vessels. It is the first form of collagen put down by fibroblasts in a healing wound or during repair. Collagen type IV: This nonfibrillar collagen is present in the pericellular basement membranes that surround some cells, such as smooth muscle cells, and in basement membranes separating tissue compartments one from another in blood vessels. Glucose-binding proteins Fibronectin is a glycoprotein that attaches to other ECM molecules and cells, acting as a scaffold and glue to hold the tissue together. Laminin is a glycoprotein that functions as an adhesive material in smooth and striated muscle cells as well as being an integral component of basement membranes. Proteoglycans: These negatively charged molecules are highly hydrophilic, and their side chains, which extend into the intercellular spaces, can bind water. Proteoglycans also act as an interstitial glue, holding other components together.
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