What is Pathology - What causes edoema in acute inflammation?
There are three main causes of inflammatory edoema:
a) Fluid transudation in capillaries and venules is aided by increased hydrostatic pressure in the microcirculation. Arteriolar dilation combined with an increased blood inflow increases fluid transudation.
b) Increased permeability of blood vessels: Under the influence of inflammatory mediators, the vessel walls of capillaries and venules become leaky, enabling plasma proteins and fluid to pass through. Hemoconcentration occurs as a result of fluid loss, which promotes blood cell stasis. Stasis is linked to high blood pressure in the venules, which prevents fluids from the interstitial spaces from returning to the bloodstream.
c) Reduced plasma oncotic pressure: Protein loss as a result of enhanced transudation or exudation will gradually lower the plasma oncotic pressure. The transport of fluid into the interstitial space is facilitated by a decrease in plasma oncotic pressure. At the same time, at the venular end of microcirculation, the return of water from the interstitial space into the circulating blood is reduced.
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