What is Pathology - What causes persistent inflammation?

What is Pathology - What causes persistent inflammation?
​Chronic inflammation can occur as a result of the following factors: 
-Chronic infections caused by pathogens that cannot be easily eliminated (e.g., viral hepatitis C or tuberculosis) 
- Nonhealing or persistent acute inflammation, such as nonhealing bacterial pneumonia
- Persistent infections caused by pathogens that cannot be easily eliminated (e.g., viral hepatitis C or tuberculosis) 
-Constant contact with harmful external effects (e.g., cigarette smoke) & Foreign material (e.g., surgical material left over in the wound)
- Autoimmune illnesses: The majority of diseases induced by endogenous antigens have a long-term course. 
-Foreign antigens commonly cause chronic immunological reactivity in both B and T cells, resulting in transplant rejection. Unknown-cause diseases: Many chronic inflammatory disorders, such as chronic inflammatory bowel disease and common interstitial pneumonitis, have no identified cause.