What is Pathology- What is Fibrinoid Necrosis?
Fibrinoid necrosis is a type of necrosis caused by fibrin. Fibrinoid necrosis is a condition that affects only tiny blood vessels. It usually involves autoimmune illnesses (e.g., systemic lupus erythematosus) or malignant hypertension affecting tiny arteries, arterioles, and glomeruli. In normal hematoxylin-eosin (H&E)–stained slides, the walls of necrotic arteries or glomeruli are coated with fibrin and look uniformly red. Other plasma proteins are present in these deposits, according to a detailed investigation; nonetheless, fibrin dominates other proteins in histologic slides, giving the lesion its name. Fibrinoid necrosis is only visible in histologic preparations and has no macroscopic symptoms.
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