What is Pathology - Which chemotactic substances are the most important?
Exogenous chemoattractants and endogenous chemoattractants are both possible. Exogenous chemoattractants are made up of bacterial polypeptides with a formulated-methionine sequence at the end. Endogenous chemoattractants, meantime, are produced by mitochondrial polypeptides released by injured cells. The following are some other key endogenous chemotactic substances: & Arachidonic acid derivatives generated by the lipoxygenase route (e.g., leukotriene B4) & Cytokines & Products of complement system activation (e.g., C5a) & Cytokines (e.g., IL-8)
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