What is Dermatology - Are there any additional types of cells in the epidermis?
In addition to keratinocytes, the epidermis contains three more types of cells. The most frequent type of dendritic cell is the melanocyte, which is found in the basal cell layer. Each melanocyte contains roughly 36 keratinocytes. Melanosomes are melanin-containing organelles that are synthesised and secreted by this cell.
The Langerhans cell, a bone marrow-derived antigen-presenting cell with critical immune surveillance functions, is the next most common cell. These dendritic cells are primarily found in the stratum spinosum under light microscopy. Paul Langerhans initially described Langerhans cells in 1868, while still a medical student.
Merkel cells can also be seen in small numbers in the epidermis. Although the function of these cells is unknown, they are commonly in contact with nerve fibrils. Merkel cells contain electron-dense structures, which are also found in endocrine gland APUD (amino acid precursor uptake and decarboxylation) cells.
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