What is Dermatology - Are there any Basement membrane zone (BMZ) and dermis blistering disorders that can be acquired?
Yes. Blisters develop as a result of disturbance of the BMZ and dermis structures in a variety of disorders. Antibodies to the hemidesmosomes and other structures inside the BMZ and dermis induce skin separation and blistering, similar to epidermal blistering disorders. Hemidesmosomes attach the basal keratinocytes to the basement membrane in the uppermost section of the BMZ, the LL. Antihemidesmosomal antibodies appear to cause inflammation and subsequent damage to the hemidesmosomes, causing a blister to form between the cells and the basement membrane in bullous pemphigoid (BP).
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