What is Dermatology - Describe the basement membrane zone's structure (BMZ).
The BMZ is generally not visible under light microscopy in sections stained with hematoxylin and eosin, but it can be seen on periodic acid–Schiff staining as a homogenous band measuring 0.5 to 1.0 mm thick. The BMZ is an extraordinarily complex structure with multiple components that function to link the basal cell layer to the dermis, according to ultrastructural investigations and immunologic mapping . The cytoplasmic tonofilaments of the basal cells, which bind to the basal plasma membrane of the cells at the hemidesmosome, are at the top of the BMZ. Anchoring filaments connect the hemidesmosome to the BMZ's lamina lucida and lamina densa.
The BMZ is anchored to the dermis by anchoring fibrils that intercalate between the dermis' collagen fibres and secure the BMZ to the dermis. Diseases like epidermolysis bullosa, in which these structures are congenitally lacking or injured, illustrate the necessity of these structures in preserving skin integrity.
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