What is Dermatology-What epidermal structural components are involved in blistering diseases?
The desmosomal complex binds the keratinocytes together in the epidermis. The desmosome and the cytoplasmic tonofilaments, which are comprised of cytokeratins, make up these complexes. Keratins 1 and 10 make up the majority of the tonofilaments in the upper stratum spinosum. Congenital keratin defects cause structural weakness between keratinocytes, resulting in the condition congenital bullous ichthyosiform erythroderma (epidermolytic hyperkeratosis). Epidermolysis bullosa simplex (EBS) is a minor blistering illness caused by abnormalities in keratin types 5 (KRT5) and 14 (KRT14) in the basal cell layers . Pemphigus is a series of acquired epidermal blistering illnesses in which autoantibodies to antidesmosomal proteins cause damage to the desmosomes.
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