What is Emergency Medicine -What is the tPA risk?
Systemic bleeding, especially ICH, is the main danger of tPA. The number needed to harm (NNH) for the NINDS study was 17, with ICH with tPA being 6.4% compared to 0.6% for the nontreatment group. ICH with tPA was 2.4% versus 0.2%, or a NNH of 45 for ECASS III (7.9% versus 3.5%, or a NNH of 23). In their extended time range of 4.5 hours since last normal, the SITS-ISTR has demonstrated a rate of roughly 2% ICH that is comparable. Older age, brain edema or mass effect on CT, and greater baseline stroke severity appear to be linked to an increased chance of bleeding. 1% to 5% of people may develop angioedema.
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