What is Emergency Medicine -Why is the use of tPA for acute ischemic stroke controversial?10/31/2022 What is Emergency Medicine -Why is the use of tPA for acute ischemic stroke controversial?
The debate is complicated on many levels. The majority of trials testing tPA in ischemic stroke reveal an increased risk of ICH and related comorbidities without a mortality benefit, which worries tPA critics. Conflicts of interest have also been a source of worry because the drug company sponsors many of the larger trials. Proponents point out that these studies indeed demonstrate a considerable increase in patients' functional mobility and capacity for independent living, a crucial result considering the prevalence of disability following stroke in the world.
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