What is Endocrinology -Between Papillary Thyroid Carcinoma (PTC) and Follicular Thyroid Carcinoma (FTC), which is simpler to diagnose using thyroid fine-needle aspiration (FNA) data?
PTC possesses unique nuclear characteristics that enable cytopathology diagnosis with a positive predictive value (PPV) greater than 95%, such as larger, overlapping nuclei with nuclear grooves, and intranuclear pseudoinclusions. On the other hand, FTC is functionally defined as the invasion of follicular cells that mainly appear normal via a tumour capsule. Pure FTC is challenging to detect based on thyroid FNA because this cannot be determined on a cytology aspirate.
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