What is Endocrinology - Describe the Paget's disease-related laboratory abnormalities.
The aberrant laboratory results linked to Paget's disease are either a reflection of increased bone growth or resorption. The serum calcium and phosphate concentrations in a patient with extensive Paget's disease should be normal unless the patient is immobilised. Increased osteoblastic activity is indicated by a higher serum alkaline phosphatase concentration. Serum osteocalcin measurements, another indicator of bone development, don't add much to the knowledge provided by alkaline phosphatase measurements. As a more accurate indicator of bone production than total alkaline phosphatase concentration, serum bone-specific alkaline phosphatase may be a valuable parameter to monitor in the treatment of monostotic illness. In comparison to measuring urinary hydroxyproline, measuring urinary pyridinium collagen crosslinks (pyridinoline) is a stronger sign of accelerated bone resorption.
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