What is Endocrinology - How does ageing affect how much you weigh?
The endocrine milieu may have an impact on significant changes in body composition that are linked to ageing and may have significant endocrine and metabolic repercussions. Body weight increases until around age 55 and then starts to fall, according to cross-sectional studies. This could be a result of the heaviest patients dying off in middle life. Prospective studies indicate that around the age of 65 to 70, weight really decreases. Whether deliberate or accidental, this loss of body weight seems to be linked to a rise in mortality, illness, and disability. In fact, there is a well-documented obesity paradox in elderly individuals, where the shift in the weight associated with the lowest overall mortality. The reason for this is unclear, but considering that purposeful weight loss is challenging to maintain, it's plausible that any prolonged weight loss may actually be accidental. When cytokine levels are elevated by illness or disease, weight loss may be predisposed to a disproportionate loss of lean mass (muscle mass), aggravating age-related "sarcopenia" and resulting in a catabolic condition. The apparent obesity paradox of ageing may possibly be due to the heterogeneity of obesity in older people; obesity that develops in adolescence or middle age is more hazardous than obesity that develops in later life. It may also be assumed that interventions in these two potentially varied groups may have different outcomes, but this has not been researched.
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