What is Endocrinology - What are Paget's disease's clinical symptoms?
The majority of Paget's disease patients (between 70% and 80%) have no symptoms. The presence of this condition is frequently inferred from radiographs taken for unrelated purposes or from an unanticipated increase in the serum alkaline phosphatase level. Bone or joint pain is Paget's disease's most typical symptom. The discomfort is frequently described as painful and dull. Less frequently seen symptoms of Paget's disease include entrapment neuropathies, which can lead to hearing loss or other neurologic deficits, headache, bone deformities, skull enlargement, fracture, change in skin temperature over an affected bone, and high-output congestive heart failure. Neurologic impairments can result from direct pressure from pagetic vertebrae on the spinal cord, spinal nerve entrapment, or bone impingement on the brain or cranial nerves leaving the skull. Long-term Paget's disease patients frequently have bone deformities. The most frequently affected bones are the long bones, clavicles, and skull, which are enlarged and have an irregular shape. There is speculation that Ludwig van Beethoven's growing frontal hyperostosis, hearing loss, and headaches were caused by advanced Paget's disease of the bones.
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