What is Endocrinology - What biochemical abnormalities are linked to vitamin D deficiency and osteomalacia and rickets?
Depending on the underlying flaw or process producing the bone illness, osteomalacia or rickets may present with different test findings. Understanding the body's reaction to hypocalcemia and being familiar with the vitamin D metabolic pathway are required to comprehend the biochemical anomalies seen in illnesses linked to aberrant vitamin D metabolism. Thus, low vitamin D levels lead to low or lownormal blood calcium concentrations in patients with nutritional vitamin D insufficiency or malabsorption, which induces increased PTH release (secondary hyperparathyroidism). Increased renal phosphate excretion, decreased serum phosphate, raised serum alkaline phosphatase levels, and decreased urine calcium excretion are all consequences of this hyperparathyroid condition.
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