What is Endocrinology -What distinguishes pretibial myxedema from generalised myxedema? Pretibial myxedema is a defining feature of Graves' illness, whereas generalised myxedema is only connected to the hypothyroid condition. When the skin condition manifests, patients with pretibial myxedema may be hypothyroid, hyperthyroid, or euthyroid. Although the pathophysiology has not been established, it has been shown that serum from pretibial myxedema patients would increase the fibroblasts' ability to produce acid mucopolysaccharides. Pretibial areas typically have these lesions because the fibroblasts there are more responsive to stimulation than those in other regions, which explains why. Stimulatory thyroid-stimulating hormone (TSH) receptor autoantibodies are considered to be the most likely option for this circulating component despite the fact that its exact nature is unknown. Researchers have also proposed that activated T lymphocytes cause fibroblast growth and acid mucopolysaccharide formation.
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