What is Endocrinology - What function does thyroxine-based suppression therapy serve?
Thyroxine suppression medication was previously used routinely under the assumption that it would shrink thyroid nodules, but randomised controlled studies, some of which included ultrasound measurements, have shown that it is unsuccessful. This finding implies that thyroid regression rather than the nodule itself was likely responsible for the apparent reduction in size of solitary nodules when determined only by palpation. Except in cases of iodine deficit and the prevention of new nodules following lobectomy in patients exposed to radiation, thyroid hormone is useless for euthyroid persons. These exclusions are hardly ever observed today. Routine TSH-suppressive thyroid hormone therapy for thyroid nodules or goitre is no longer recommended since it is likely to have more iatrogenic side effects than benefits.
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