What is Endocrinology - What histologic changes are caused by Paget's disease in bones?
An increased number of massive multinucleated osteoclasts, some of which have up to 100 nuclei, are present in greater numbers in the early lesions of Paget's disease. Large numbers of active osteoblasts are found producing bone at locations of earlier osteoclastic bone resorption during the mixed osteolytic-osteoblastic phase. In areas of high osteoblastic activity, bone deposition is chaotic (in a mosaic or woven pattern) as opposed to the regular bone's ordered lamellar pattern. Paget's disease-related woven bone is structurally weaker than healthy lamellar bone, which accounts for the propensity of pagetic bone to shatter or deform.
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