What is Endocrinology- What is the bone-related Paget's disease complication that is the most severe?
The development of malignant sarcoma in pagetic bone is the most severe side effect of Paget's disease. Although such tumours are mostly solitary, 20% may be multicentric. Fortunately, less than 1% of people with clinically obvious Paget's disease experience this uncommon consequence. Paget's sarcoma is a highly aggressive tumour, and the average patient survival time is under a year. The most typical locations for sarcomatous transformation are the pelvis and long bones (humerus, femur, and tibia). Although chondrosarcomas and fibrosarcomas have also been documented in bone afflicted by Paget's disease, the tumour is typically an osteogenic sarcoma. Typically, a biopsy of the affected bone serves as a diagnosis. Paget's disease is also linked to other bone neoplasms, such as benign giant cell tumours, however these tumours do not have such a dire prognosis.
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