What is Endocrinology - What is the generalised myxedema pathogenesis?
The skin exhibits an increased buildup of dermal acid mucopolysaccharides, the most significant of which is hyaluronic acid (ground substance). Studies have also shown that the appearance of edoema is exacerbated by an enhanced transcapillary escape of serum albumin into the dermis. Both of these alterations can be reversed with replacement therapy; neither is permanent.
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