What is Endocrinology - What radiographic analysis is most effective for assessing the severity of Paget's disease?
Since osteoblastic pagetic bone lesions readily absorb technetium-labeled bisphosphonate, radionuclide scanning is the best method for determining the metabolic activity of these lesions. Bone scans can detect 15 to 30 percent of pagetic lesions that are not visible on radiographs, despite having a lower diagnostic specificity than radiographic tests. In contrast, the diagnosis of relatively inactive or "burned out" Paget's disease is most likely when radiographs show pagetic involvement but the blood alkaline phosphatase level is normal and the bone scan shows little isotope uptake at those areas. On a bone scan, lesions that are mostly lytic in nature (such osteoporosis circumscripta) might not be seen. Magnetic resonance imaging (MRI) and computed tomography (CT) offer little to the diagnostic process for patients with simple Paget's disease.
0 Comments
Leave a Reply. |
Kembara's Health SolutionsDiscovering the world of health and medicine. Archives
June 2023
Categories
All
|