What is Endocrinology - What three stages of Paget's disease of the bone are there?
There are three main phases in the development of Paget's disease. The first stage is described as an osteolytic phase with a predominance of osteoclastic bone resorption. In between 1% and 2% of cases, this fully lytic phase is present. As the osteolytic phase progresses, overactive osteoclastic and osteoblastic cells are seen. A phase with less active bone remodelling and obvious sclerosis follows this mixed phase. Excessive osteoblastic bone deposition is predominant in this final stage. The majority of people who seek medical attention have symptoms consistent with this stage.
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