What is Endocrinology - When should a pagetic bone lesion be suspected of having malignant sarcoma?6/30/2022 What is Endocrinology - When should a pagetic bone lesion be suspected of having malignant sarcoma?
The emergence of new or intensifying bone pain and/or soft tissue swelling typically signals the beginning of malignant transformation inside pagetic bone. Radiographs frequently reveal the progressive breakdown of pagetic bone. Less frequently, sclerosis that is worsening or masses of thick, amorphous deposits in the bone are indicators of malignant transformation. In an otherwise stable patient, the serum levels of alkaline phosphatase may increase quickly. In the vicinity of the tumour, radionuclide absorption is typically reduced as seen on bone scans. Additionally, gallium scans reveal higher uptake in the affected area (s).
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