Ebola hemorrhagic fever
Ebola hemorrhagic fever is caused by Marburg virus and Ebola virus. Marburg and Ebola viruses are filoviruses.
Serology test is considered in detecting the virus specific IgG or IgM and polymerase chain reaction and immunoassay able to detect the DNA of the virus or antigen.
There will be an increase in the release of cytokines which lead to an increase in the vascular permeability.
The Ebola and Marburg viruses may infect the macrophages. The virus will spread via vascular system and lymphatic system and affecting the liver and spleen causing the necrosis of the spleen and the liver.
Patient may present with destruction of large cells and tissues with hemorrhage and shock. Patient may die due to shock and multi organ failure.
Patient may present with sudden onset of fever, abdominal pain, myalgia, malaise, joint pain, muscle pain, nausea, vomiting and diarrhea.
The condition may progress to bleeding into the mucous membrane, skin and visceral organs.
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