What is Microbiology - Hepatitis A
Hepatitis A is caused by hepatitis A virus. Hepatitis A virus is detected via HAV specific IgM antibody.
Hepatitis A virus is a form of picornavirus. Hepatitis A virus will be transmitted via fecal oral route. The ingestion of hepatitis A virus will infect the oropharynx and gastrointestinal tract before spread to the liver.
Cytotoxic T cells will be activated which lead to injury of the hepatocytes. Hepatitis A virus later will be excreted in the feces.
Proper sanitation and personal hygiene is recommended to prevent the spread of hepatitis A virus which is a food borne or water borne infection.
The common symptoms and signs of hepatitis A are fever, nausea, vomiting and anorexia. Patient may also suffer from jaundice with dark urine ( bilirubinuria).
The treatment may include HAV immune globulin passive immunization for post exposure prophylaxis and inactivated HAV vaccine for at risk individual for hepatitis A virus infection.
Rare complications of hepatitis A may include fulminant hepatitis, liver failure and death.
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