Neisseria Gonorrhoeae infection
Neisseria gonorrhoeae may causes urethritis, proctitis, cervicitis, pharyngitis. arthritis, pelvic inflammatory disease, sepsis, skin and joint infection.
The common mode of transmission may include sexual contact or vaginal delivery of the newborn.
Neisseria gonorrhoeae is gram negative diplococcus which can be cultured on chocolate agar or Thayer - Martin. The sample for gram stain in woman is taken from the vaginal discharge which in men direct gram stain of the purulent discharge may reveal the present of gram negative diplococci.
Nesisseria gonorrhea contain cell wall lipooligosaccharides which is an endotoxin, por protein which involves in intracellular survival, pilin and opa protein which facilitate invasion and attachment. The variation in antigenic and phase leads to the escape from humoral immune response.
The treatment may include antibiotic such as third generation cephalosporin and fluroquinolones. Gonococcal infection of the eyes in newborn is prevented with chemoprophylaxis ( silver nitrate eye drops).
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