Progressive multifocal leukoencephalopathy
Progressive multifocal leukoencephalopathy is caused by human polyomavirus ( JC virus).
JC virus is detected by polymerase chain reaction of the brain biopsy or cerebral spinal fluid of the patient. Other technique may include in situ DNA hybridization.
Progressive multifocal leukoencephalopathy is associated with AIDS. JC virus is transmitted via respiratory droplets. Progressive multifocal leukoencephalopathy may lead to demyelinating disease mostly in the brain . Progressive multifocal leukoencephalopathy may initially present with alteration of the mental status , abnormalities of the vision and abnormalities of the speech. Patient may fall into coma and death.
JC virus may establish latent infection in multiple organs. JC virus may lead to opportunistic infection of the brain mostly in patient with immunosuppressive therapy, AIDS patient and currently on therapy for organ transplantation.
JC virus will be activated and spread to the brain. This will lead to lytic destruction of oligodendrocytes.
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