Whooping cough is caused by gram negative rod Bordetella pertussis.
Bordetella pertussis is detected by culture media with high nicotinamide. Whooping cough present with symptoms such as paroxysmal coughing, fatigue and copious production of mucus. Bordetella pertussis is highly infectious and the mode of transmission is via airbone droplets.
Bordetella pertussis will block the normal mechanism of respiratory clearance. Bordetella pertussis will bind to the ciliated respiratory epithelial cells by filamentous hemagglutinin. Pertussis toxin is a form of A-B toxin which will lead to activation of the adenylate cyclase of the host while cyclolysin is the adenylate cyclase of the bacterial. Pertussis toxin and cyclolysin will lead to elevation of cAMP which finally cause an increase in the secretion of mucus.
The common treatment of whooping cough may include supportive care such as supplemental of oxygen and suction or the mucus from the respiratory system. Antibiotic such as erythromycin is considered. Acellular vaccine ( against pertussis toxin ) is also considered.
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