​What is Nephrology - What are some of the most prevalent symptoms and indicators associated with advanced kidney disease?

​What is Nephrology - What are some of the most prevalent symptoms and indicators associated with advanced kidney disease? 
In its early stages, chronic kidney disease is characterized by nonspecific signs and symptoms and can only be identified by an increase in serum creatinine.
Symptoms • Appetite loss or reduction (protein aversion)
• Fatigability 
• Fatigability  
• Mental changes (e.g., lethargy, stupor, inability to concentrate) 
• Nausea, vomiting, and dyspepsia are all symptoms of dyspepsia. 
• Generalized itching or pruritus 
• Seizures 
• Breathing difficulties 
• Edema 
• Intractable hiccups 
• A "frothy" urine appearance (typically due to proteinuria) 
• Erectile dysfunction (e.g., erectile dysfunction) causes a decrease in sexual interest. 
• Legs that are restless 
• Pallor 
• Elevated blood pressure (BP) (from anemia) 
• Asterixis and myoclonus (uremic encephalopathy) 
• Volume overload (jugular venous distention, peripheral edema, pulmonary edema, anasarca) 
• Friction rub (pericarditis)