What is Pathology - Give a few examples of necrosis that is liquefactive.
Brain infarct: The necrotic area softens (encephalomalacia), and macrophages phagocytize the necrotic tissue debris. Diffusion of fluid from the surrounding interstitial spaces of the brain fills the residual void ("the body abhors a vacuum"). A fluid-filled pseudocyst like this can last indefinitely.
Abscess: This is caused by a purulent infection that is localised. It usually manifests as a pus-filled cavity, which is made up of liquefied tissue from the diseased organ infiltrated by dead and dying neutrophils.
Wet gangrene of the extremities: This is a type of coagulative necrosis with a bacterial infection that is commonly found in diabetic individuals. Bacterial lytic enzymes break down the tissue, causing it to liquefy.
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