What is Pathology - How does the complement system work?
The classical, alternative, and lectin-binding pathways are three convergent methods that can activate the complement system.
a) Classical pathway: This was termed after the discovery of the pathway during the development of antigen–antibody immune complexes many years ago.
b) Alternative pathway: Foreign chemicals, poisons, and enzymes, as well as pieces of bacteria and fungi, activate this pathway.
c) The mannose-binding protein (MBP), a liver-derived plasma protein, initiates the lectin-binding pathway. MBP binds to mannose residues on the bacterial plasma membrane and is a key player in the bacterial inflammatory response.
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