What is Pathology - Paget’s Disease
Pathophysiology • An age-related illness in which osteoclastic activity is followed by an excessive osteoblastic response, leading to bone growth. • There are three phases: the active phase (reabsorption), the mixed phase (osteoblast activity), and the dormant phase (where osteoblastic phase activity has surpassed osteoclastic phase activity). • An increased blood supply to the bones. • The most frequently impacted bones are the femur, skull, vertebrae, and pelvic. Evaluation and Diagnostic Results • Nuclear bone scans that reveal "hot spots" of abnormally rapid bone cell turnover that look overgrown or have a mosaic pattern, as well as elevated ALP. The levels of the bone resorption markers Pyrilinks and Osteomark in urine samples are increased in Paget's disease. Complications • decreased cardiac production brought on by vasodilation. • Pain and disfigurement. • Neuropathy. • Aortic insufficiency with calcium. • Pneumonia and decreased thoracic cage compliance. Medical Attention and Surgical Procedure • The inhibition of osteoclasts and osteoblasts with calcitonin, biphosphonates, and anticancer/antibiotics (plicamycin, for example). Anti-inflammatory medications. • Painkillers. • Describe your pain on a measure of 0 to 10, as well as any dizziness or dyspnea. • While receiving therapy, report any bleeding from an orifice or the gums. • Use plicamycin treatment while monitoring CBC for low platelet levels. • Adjust painkiller dosages to maintain a pain threshold of 3. • Track serum and pee tests to gauge a treatment's efficacy.
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