What is Pathology - Rheumatoid Arthritis
Pathophysiology of Rheumatoid Arthritis • Rheumatoid arthritis is a widespread illness with autoimmune and genetic roots. More women than males are impacted. Antibodies against the rheumatoid factor (RF) interact with IgG to create immune complexes in the bloodstream and in synovial joints. • Immune complexes are phagocytosed by granulocytes, which then discharge toxins into the joints and surrounding tissue. • Vascular pannus is produced as a result of synovitis and an increase in blood vessel growth in the synovial membranes. • In an effort to heal damaged tissue, the inflammatory region is "walled off," which results in more immobility and damage. Evaluation and Diagnostic Results • The existence of RF, anti-CCP antibodies, elevated WBC levels, and elevated ESR. • A large amount of neutrophils are found in the synovial fluid upon examination. • Low-grade fever, flu-like symptoms, joint inflammation on both sides, joint malformations like swan neck malformation, and nodal development. Complications include discomfort, paralysis, and joint deformity or ankylosis. • Leukopenia, scleritis, pulmonary, and cardiac irritation. medical attention and surgical procedure • Corticosteroids, salicylates, NSAIDs, gold ions, TNF inhibitors, and DMARDs. • Joint replacement surgery. • Occupational and physical training to keep the body functioning. • Always consume anti-inflammatory medications with meals. Immediately report any infection-related symptoms. While taking anti-inflammatory medications, keep an eye out for infectious symptoms in the CBC. • Help with ROM workouts to keep mobility.
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