What is Pathology - What are granulomas, exactly?
Granulomas are clumps of epithelioid macrophages and lymphocytes, with the occasional multinucleated giant cell, that are the characteristics of granulomatous inflammation. The cytoplasm of epithelioid macrophages is loaded with vacuoles and lysosomes, which distinguishes them from other macrophages. Their cell boundaries are close together, giving the structure a "epithelioid" appearance (i.e., it resembles the epithelial layer of the skin).
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