​What is Pathology - What are the indications and signs of irreversible cell damage?

What is Pathology - ​What are the indications and signs of irreversible cell damage?
The distinctions between reversible and irreversible cell damage are first purely quantitative. Hypoxic vacuoles, for example, grow more numerous and larger. The mitochondria have swelled and some have ruptured. Many of these changes, however, are still reversible, and it is only when the plasma membrane ruptures and nuclear alterations occur that a damage is irreversible and the cell dies.