​What is Pathology - What causes inflammation-related leukocytosis?

​What is Pathology - What causes inflammation-related leukocytosis? 
An rapid release of leukocytes from the bone marrow causes leukocytosis, which is defined as a two- or threefold increase in the quantity of leukocytes in the peripheral blood (typically >12,000 leukocytes per microliter). IL-1 and TNF-a, which are produced by inflammatory cells at the site of inflammation, are responsible for the bone marrow response. If the inflammation continues, macrophages and T lymphocytes will create colony-stimulating factors (CSFs), which help the bone marrow produce new leukocytes.