What is Pathology - What compounds can build up inside cells?
Exogenous and endogenous substances collecting inside cells can be categorised. Carbon particles inhaled from contaminated air accumulating in macrophages in anthracosis, for example, or pigment used in skin tattooing are examples of exogenous chemicals. The following are examples of endogenous chemicals that accumulate in cells:
Lipids: Triglyceride accumulation in hepatocytes results in fatty liver (hepatic steatosis).
Proteins: The development of cytoplasmic globules is caused by the accumulation of a1-antitrypsinin hepatocytes. In congenital glycogenoses, glycogen accumulates in the liver and many other organs.
Lipofuscin: This lipid-rich brown pigment of ageing builds up in various organs as people age and as they develop chronic diseases.
Hemosiderin: In congenital hemochromatosis or patients who have received many transfusions, this iron-rich brown pigment accumulates in the liver and many other organs.
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