What is Pathology - What happens to cardiac cells as they undergo hypertrophy?
Cardiac myocytes that are hypertrophic expand. They gain more cytoplasm and their nuclei grow during this process. More contractile proteins are found in the cytoplasm. In proportion to the total cell mass, the amount of DNA and RNA in the nucleus increases. Some genes in hypertrophic cells are not expressed in normal cells. Oncogenes (e.g., c-fos and c-jun) and genes for proteins expressed only in foetal life (e.g., myosin heavy chain and atrial natriuretic factor) are among the genes whose function is unknown.
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