What is Pathology - What is fibrinous inflammation, and how does it affect you? Fibrinous inflammation is caused by fibrin-rich exudates. Fibrinogen, a high-molecular-weight plasma protein, can only depart the blood vessel wall through big flaws, therefore fibrinous inflammation implies vessel wall injury or increased vascular porosity. Fibrinous exudates are made up of a fibrin meshwork (i.e., polymerized fibrinogen). The fibrin in the exudate creates strands that bridge the space between the epicardium and the pericardium, giving the pericardial cavity a "bread and butter" appearance. Mycobacteria (e.g., Mycobacterium tuberculosis) can produce fibrnous pericarditis, although it can also be sterile and result from rheumatic fever, uremia, or even a transmural myocardial infarction.
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