What is Pathology - What is the difference between apoptosis and necrosis?
Single cells are normally affected by apoptosis, whereas larger groupings of cells or tissues are affected by necrosis. During necrosis, there is no gene activity and most cytoplasmic maintenance enzymes are inactivated; during apoptosis, enzyme activation and inhibition are controlled sequentially by genes. Cells inflate (oncosis) during necrosis, and the cytoplasm and nucleus of cells disintegrate into apoptotic bodies during apoptosis. Neutrophils phagocytize necrotic cells, which cause an inflammatory response. Nonprofessional phagocytes, such as adjacent cells or macrophages, phagocytize apoptotic materials.
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