What is Pathology - What organs are capable of pure hypertrophy?
Only the heart and skeletal muscle experience pure hypertrophy without hyperplasia. Because myocytes in the heart muscle are terminally differentiated and unable to divide, a greater demand for activity can only be fulfilled by increasing the number of the muscle cells. The heart is immune to hyperplasia. Reserve cells in skeletal muscles may potentially divide and contribute to muscle mass, but this never happens under normal circumstances. Muscle cell hypertrophy meets the demand for more effort in this way.
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