​What is Pathology - What role do macrophages play in chronic inflammation?

​What is Pathology - What role do macrophages play in chronic inflammation? 
A variety of physiologically active chemicals are produced and secreted by macrophages, including: 
- Cytokines, such as IL-1 and IL-2, which regulate the actions of other cells
 - Chemokines, which draw in more macrophages and lymphocytes to the location 
- Bacteria and other cells are killed by free oxygen radicals. Growth factors, such as fibroblast growth factor (FGF) and platelet-derived growth factor (PDGF), stimulate the growth of other cells, particularly fibroblasts and angioblasts in granulation tissue during wound healing; -Proteases, which remove damaged tissue elements;
 - Arachidonic acid metabolites, which amplify inflammation