What is Pathology - What role do macrophages play in chronic inflammation?
A variety of physiologically active chemicals are produced and secreted by macrophages, including:
- Cytokines, such as IL-1 and IL-2, which regulate the actions of other cells
- Chemokines, which draw in more macrophages and lymphocytes to the location
- Bacteria and other cells are killed by free oxygen radicals. Growth factors, such as fibroblast growth factor (FGF) and platelet-derived growth factor (PDGF), stimulate the growth of other cells, particularly fibroblasts and angioblasts in granulation tissue during wound healing; -Proteases, which remove damaged tissue elements;
- Arachidonic acid metabolites, which amplify inflammation
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