What is Pathology - What role does the antiapoptotic protein Bcl-2 play in B-cell lymphoma pathogenesis?
Bcl-2 is a protein that generally prevents cells from dying. Its name comes from the fact that it was first discovered in B-cell lymphoma cells. In B-cell lymphoma cells, it is encoded by a gene that is overexpressed. Bcl-2 stops lymphoma cells from dying, making them "immortal." These cells build up in lymph nodes and survive the host, who is usually killed by the immortal tumour cells.
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