What is Pathology - Which inflammatory mediators behave as pyrogens?
Exogenous pyrogens (fever-inducing chemicals) trigger macrophages to create endogenous pyrogens such IL-1, TNF-a, and IL-6. PGE2 operates on the hypothalamus thermoregulatory centres, raising the thermostat for body temperature. IL-1 increases the manufacture of PGE2, which acts on the hypothalamic thermoregulatory centres, raising the thermostat for body temperature. TNF-a and IL-6 increase the synthesis of IL-1 as well as acting directly on the hypothalamus.
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